Skip to main content

Cost-effectiveness of palivizumab in infants with congenital heart disease: a Swedish perspective



Infants with congenital heart disease (CHD) have an increased risk of morbidity and mortality during a respiratory syncytial virus (RSV) infection. The aim of this study was to estimate the cost-effectiveness of palivizumab as RSV-prophylaxis among infants with CHD, including the effect of delayed heart surgery and asthma.


A simulation model with data from the literature and health care authorities including costs and utilities was developed to estimate costs and health effects over a lifetime for a cohort of CHD infants receiving palivizumab compared to no RSV-prophylaxis.


The prophylaxis treatment incurred a cost of 3664 EUR per treated infant. However, due to cost-savings from primarily avoiding hospitalizations (5145 EUR/treated infant) and avoiding heart complications due to delayed heart surgery (2082 EUR/treated infant), the RSV-prophylaxis treatment resulted in a total cost-saving of 3833 EUR per treated infant. At the same time, the prophylaxis-treated cohort accumulated more life-years and higher quality of life than the non-prophylaxis cohort.


This study confirms that RSV-prophylaxis in severe CHD infants less than one year of age is cost beneficial. Avoiding delayed heart surgeries is an important benefit of prophylaxis and should be taken into consideration.


Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections (LRTI) in infants and young children. Severe RSV may result in acute respiratory failure and hospitalization with supplemental oxygen, mechanical ventilation, and intensive care (ICU), especially for infants and children at risk [1, 2]. Infants with congenital heart disease (CHD) carry a risk of morbidity and mortality from RSV infection worldwide as well as in Scandinavia [3, 4]. Long-term sequelae from RSV-infections are wheezing and asthma [5,6,7,8].

Cardiac surgery performed during an ongoing RSV infection is associated with a high risk of postoperative complications, prolonged postoperative stay at the pediatric intensive care unit (PICU), and morbidity [9,10,11]. Postponing cardiac surgery is thus appropriate in infants with symptomatic viral respiratory infection. However, postponing will, on the other hand, increase the risk of morbidity and mortality induced by the cardiac disease.

Palivizumab (Synagis®, MedImmune) is a monoclonal antibody designed to provide passive immunity against RSV – thereby reducing the severity of RSV infection in infants at high risk, including infants with CHD [12,13,14].

Cost-effectiveness analyses of palivizumab in infants and children with CHD have previously been done, where most studies compared palivizumab prophylaxis to no prophylaxis with the results suggesting cost effectiveness [15,16,17,18,19]. Most studies were performed in high-income countries and only one in Scandinavia for over 16 years ago [20]. Significant variance exist across these study characteristics such as age of the included children, duration of assessed RSV seasons, primary outcome measures evaluated, sensitivity analyses conducted, and other model assumptions [21].

The aim of the present study was to estimate the cost-effectiveness of palivizumab as RSV-prophylaxis according to national guidelines among Swedish infants with CHD, including delayed heart surgery, risk of asthma, and costs related to parental care (Additional file 1).


This analysis was based on a Markov model [22, 23] with annual cycles comparing the cost-effectiveness of palivizumab as RSV-prophylaxis to no prophylaxis for Swedish infants with CHD. The simulated population was treated with RSV-prophylaxis to infants aged up to one year with hemodynamic significant CHD and subject to the national Swedish prophylactic program for palivizumab [24]. The analysis was performed from a societal perspective with a lifetime time-horizon and quality-adjusted life-years (QALYs) as the health outcome. Results are expressed in incremental cost-effectiveness ratios (ICER; euros [EUR]/QALY). Costs and effects were discounted at 3% annually as per the Swedish Dental and Pharmaceutical Benefits Agency (Tandvårds- och Läkemedelsförmansverket, TLV) guidelines [25]. All costs in this study were calculated in Swedish krona (SEK) based on the health-care price-level of 2019 and expressed in EUR in year 2019 values (1 EUR = 10.5892 SEK).

Model structure

The health states and possible transitions of the Markov model are shown in Fig. 1. The model structure was similar to the structure used in previously published cost-effectiveness analyses of RSV-prophylaxis [16, 23], but with the addition of possible complications from delayed heart surgery, costs due to parental care and risk of asthma. The simulation was started during the first year of life for a cohort of Swedish infants with CHD subject to RSV-prophylaxis according to national guidelines [24]. At the start of the RSV-season, a proportion of these infants would be infected with RSV leading to RSV-hospitalization, and in some cases even death. RSV-hospitalization was modeled to delay the planned heart surgery in an estimated number of cases affected by RSV during the winter season, where the risk of CHD-associated complications, including death, would rise. During the future years of simulation, the infants were subjected to a risk of asthma – with a higher risk for those with a history of RSV-hospitalization. The prevalence of the CHD-associated complications was unchanged from the first year. Mortality risks were identical for all children with CHD after the first year. For the RSV-prophylaxis cohort, palivizumab was modeled to be administered only during the RSV season of the first year of simulation.

Fig. 1

The structure of the Markov model

Risk data and treatment effects of palivizumab

For the palivizumab-treated cohort the following direct treatment effects were modeled based on the randomized clinical trial on palivizumab in CHD infants [13]:

  • Lower risk of RSV-hospitalization

  • Less severe RSV-infection if hospitalized

Data related to RSV-infection and hospitalization, continuous positive airway pressure (CPAP), extracorporeal membrane oxygenation (ECMO) and RSV-related death, as well as asthma following RSV, have been retrieved from well-known studies [7, 13, 26,27,28,29,30,31]; hospital economists at one of the hospitals (Linköping) were consulted when data was not available (Table 1). After 18 years of age, no further difference in the prevalence of asthma was assumed in the present analysis.

Table 1 Input data used in the model

The risk of death has been estimated to a hazard ratio (HR) of 64 for the group of children born during the 1990’s with the most severe defects and would be included in the national prophylactic program of palivizumab [40]. Survival rates have improved among children born as of 2010, and the survival rates are thus expected to improve to approximately 80% [41, 42].

The risk of delayed heart surgery due to RSV-hospitalization was 30%, based on information from a Swedish study from 2014 on adherence to guidelines of palivizumab – where 30% of children with prophylactic treatment had their operation delayed [43]. Among infants with delayed heart surgery, around 40% were estimated to have heart complications (expert opinion within the group).

Cost data

Cost of palivizumab

The cost of palivizumab was based on five injections with a dose of 15 mg/kg at a cost of 8.25 EUR per mg (Table 1). We assumed that some children were born late during season and therefore not in need of all five doses, but some were older at start of season and outgrew the national guidelines recommended age during season. Thus, we assumed for the calculations that the overall number of children during a season and we accounted for five doses during the season.

Data on weight of infants were retrieved from 30 patients with severe CHD receiving RSV-prophylaxis according to national guidelines at Linköping Children’s Hospital. In this dataset, the mean weights at dose 1, 2, 3, 4, and 5 of palivizumab were 5.0 kg, 5.4 kg, 5.8 kg, 6.4 kg and 7.0 kg, respectively. The resulting cost of RSV-prophylaxis per infant and season was 3664 EUR (Table 1).

Cost of RSV-hospitalization

Data on cost of hospitalization, supplementary oxygen, mechanical ventilation, CPAP, and ECMO are presented in Table 1. In Sweden, parents are provided parental allowance if the child is hospitalized. The cost for the society for this was estimated to be 118 EUR per day based on data from Statistics Sweden [35]. Mean length of hospitalization (10.8 days with prophylaxis vs. 13.3 days without prophylaxis) and ICU days (3.0 days with prophylaxis vs. 7.3 days without prophylaxis) were calculated based on Feltes et al. [13]. The resulting total costs per RSV-hospitalization, when combined with the length of stay data, was 96,918 EUR for prophylaxis treated infants and 106,344 EUR for non-treated infants (Table 1).

Cost of CHD-associated complications following postponed operation and RSV-sequalae as asthma

The costs of a general CHD-associated complication following delayed heart surgery was calculated as the value of 100% productivity loss, assuming that one parent would initially need to be at home full-time with the infant, and that all the individuals with these heart complications do not enter the labor market as adults. The resulting annual cost of a general CHD-associated complication using these assumptions was 21,506 EUR (Table 1). The annual cost of asthma per infant has been gathered from estimations [23] building on studies on adults [44] and preschool children [45].

Utility data

The utility of the modeled CHD-infants was assumed to be equal to the utility of premature infants as previously described by Greenough et al. [37]. The base utility was accordingly set to 0.89 for all infants, with a decrement of 0.10 (assumed) for those RSV-hospitalized. Asthma and CHD-complications further decreased the utility, as shown in Table 1.

Sensitivity analysis and scenario analysis

One-way sensitivity analysis was used to test the robustness of the results for alterations in individual input data items by separately increasing/decreasing each variable by ±50%, except for the utilities, which generated a range of the ICER for each variable.

Probabilistic sensitivity analysis using Monte-Carlo simulation [22, 23] was used to investigate the uncertainty around the ICER, presented as an ICER scatter plot.

The effect on the ICER of shorter time horizons of the analysis; excluding the consequences of delayed heart surgery; excluding asthma and RSV-mortality; and using the mortality of the general population was investigated in scenario analyses.


The results of incidence in different outcomes from the simulation model are shown in Fig. 2. Palivizumab had the greatest impact compared to the non-prophylaxis cohort in terms of hospitalizations. There was an increased incidence in other outcomes, but with less of a difference to prophylactically treated children with CHD.

Fig. 2

Incidence of different outcomes for the two cohorts in the model


The mean costs, effects, and ICER per infant in the base case scenario are shown in Table 2. The prophylaxis treatment incurred a cost of 3664 EUR per treated infant. By avoiding RSV-hospitalizations and morbidity associated with RSV infection as a result of prophylaxis, substantial savings mainly due to fewer days in the ICU and fewer days with ECMO were generated. The lower incidence of asthma and complications due to delayed surgery in the prophylaxis-treated cohort also generated savings. Over a lifetime, the prophylaxis was estimated to result in a cost-saving of 3833 EUR per CHD infant. In addition, the prophylaxis-treated cohort accumulated more life-years and higher quality of life than the non-prophylaxis cohort, resulting for the base case in a gain of 0.06 QALYs.

Table 2 Costs, effects and incremental cost-effectiveness ratios (ICER) for the base case scenario. Data indicate mean values per infant

Sensitivity analysis and scenario analysis

Results from the one-way sensitivity analysis of the base case are shown in Table 3. When changing the variable values by ±50%, respectively, the prophylaxis treatment arm remained dominant (lower costs and higher utilities) in all cases except when the HR for RSV hospitalization of children treated with prophylaxis was increased by 50%. In that case, the ICER was 7875 EUR/QALY which, with a high margin, still would be regarded as very cost-effective [46].

The results from the probabilistic sensitivity analysis (Fig. 3 in Appendix) showed that the probability of RSV-prophylaxis to be cost-saving compared to no prophylaxis was close to 100%, given the joint uncertainty of the input data (Table 3 in Appendix).

In scenario analyses, a shorter time horizon of the analysis was shown to have the greatest impact on the cost-effectiveness of RSV-prophylaxis (Table 4 in Appendix). The prophylactic treatment was however still dominant when the time horizon was set to only 1 year as opposed to lifetime in the base case. Excluding asthma and RSV-mortality had a clear impact on QALYs but only minor effects on the costs, still leading to cost-savings and higher utility. If the effect of delayed heart surgeries due to RSV-hospitalization was removed from the model, the cost savings were lowered to 1751 EUR and the incremental QALYs to 0.05. If using the mortality from the general population in the model instead of the adjusted mortality for CHD infants used in the base case, the cost-savings and utility of prophylaxis would be even greater.


The cost-effectiveness for RSV-prophylaxis with palivizumab as compared to no prophylaxis among Swedish CHD-infants aged less than 1 year during RSV-season and with cardiac defects adherent to the current national guidelines of prophylaxis showed that RSV-prophylaxis was associated with not only improved health effects, but also cost-savings of 3833 EUR per infant. The analysis included hospitalization, delayed surgery, asthma, and death as well as cost associated with parental care due to a child being hospitalized for RSV.

RSV-prophylaxis was cost-effective in CHD-infants who are included in the prophylactic program in this present study. In addition to more commonly used cost-driving entities such as hospitalization and mechanical ventilation in the ICU, we included an effect of delayed surgery, parental productivity loss, and asthma. The results remained unaltered when the robustness was tested, and these characteristics were excluded from the analysis. There has been notable variance in included study characteristics, analytic models utilized, duration of RSV seasons assessed, primary outcome measures evaluated, and sensitivity analyses conducted along with other model assumptions in other studies on cost-effectiveness on palivizumab in children with CHD. Thus, comparing results can be difficult and the cost effectiveness may to some extent still be inconclusive [21, 26]. Some of the earlier studies have evaluated short-term benefits, such as reducing hospitalizations and associated costs, while more recent studies have included long-term benefits such as asthma, QALYs, or life-years gained (LYG). Most of the studies performed in the high-income countries have shown that palivizumab in children with hemodynamically congenital heart disease is cost effective [16,17,18,19, 47, 48].

Congenital cardiac surgery performed during RSV infection is associated with a high risk of peri- and post-operative complications and mortality [9, 11]. These risks are of higher severity among the youngest patients and with more severe types of CHD. Thus, if a child is infected by RSV less than 6 weeks prior to heart surgery, this operation is often delayed. A delayed operation may however further increase the cardiac morbidity with increased cyanosis and/or heart failure. Previous cost-effectiveness studies of RSV-prophylaxis for children with CHD have not included the impact of delayed surgery. We found the cost-effective impact as well as health and quality of life factors in children with CHD were improved by RSV-prophylaxis.

The risk of RSV-hospitalization and the treatment effect of RSV-prophylaxis among CHD-infants in our study were retrieved from a large randomized control trial [13]. The impact of these variables was tested in sensitivity analyses in the present study. The results showed that even if the risk of RSV-hospitalization or the effect of RSV-prophylaxis were very low (half of the base case value), the ICERs were still well below the threshold of being very cost effective given the high disease severity of this patient population.

As a long-term complication to RSV infection, asthma has been included in previous studies of cost-effectiveness analyses covering RSV-prophylaxis with palivizumab in sensitive children [16, 17, 47]. Specific data of the risk of asthma following RSV among children with CHD is lacking. The risk for asthma following RSV infection in otherwise healthy Swedish infants was used in the analysis [28]. However, CHD infants may have a different risk of asthma. A scenario analysis was performed to rule out this risk, showing that even if asthma would be completely excluded from the analysis, palivizumab as RSV-prophylaxis would still result in cost-savings. One previous study in premature infants has suggested that prophylactic treatment with palivizumab may reduce subsequent recurrent wheezing [49]. The effect on asthma and wheezing following RSV infection on children with CHD with palivizumab is not known.

Productivity costs due to temporary parental allowance and productive loss was included in the analysis but had a minor impact on the outcome. Swedish parents are provided parental benefit when their child is sick at home or hospitalized. Given the lack of robust evidence regarding the extent of parental care or short-term absence to take care of the child when hospitalized, our estimates should be interpreted with caution. Some other studies have included costs related to parental care of the child with similar results. However, these studies are performed in countries with different socioeconomic systems and the only study in Scandinavia did not include this as well as several other cost components in the analysis [17, 19, 20, 47].

The results from the analysis in this study may be underestimating the cost-effectiveness of RSV-prophylaxis, as only the effect on very severe RSV-infections leading to hospitalization was included. Costs associated with outpatient RSV bronchiolitis and treatment is difficult to ascertain but may have influenced our results. Furthermore, a decreased quality-of-life while waiting for a delayed heart surgery was not included in the calculation which if included would have contributed to higher QALY gains. Palivizumab is injected monthly intramuscularly by pediatric nurses at each pediatric cardiac center at a university- or county hospital. Costs associated with travel for clinic visits, injections, or nurse consultations have not been included in the analysis. Further, when the sterile seal of a vial is broken there may be some surplus of the drug not being used, and should maybe have been included in the costs. In our hospitals (Crown Princess Victoria Children’s Hospital University Hospital and Sahlgrenska University Hospital) this is a minor issue, as nurses often collect all children for prophylactic treatment timely to reduce the costs. Although some of the above mentioned issues have been accounted for in some other studies, an inclusion of these data is not likely to alter our results [17, 19].

Omitting or delaying palivizumab prophylaxis has been linked to increased rates of re-hospitalization. A previous Swedish study has found a delay in the start of prophylactic treatment among almost half of the children in the prophylactic program [43]. The results from our study indicate that timing and correct diagnosis of CHD is essential to benefit from cost-effectiveness of prophylactic treatment.

The cost-effectiveness shown in our study is based on the national guidelines on prophylactic treatment with palivizumab for children with CHD in Sweden [24] but the cost of the drug is a major concern. Our study used current Swedish guidelines in the analysis, which includes prophylactic treatment to the most severe types of CHD. Strict patient selection criteria are essential and use of palivizumab in a broader population than recommended in the guidelines is not justified by our study. In a recent Swedish study, the risk of RSV hospitalization for less severe cardiac defects was equal to that of severely ill children [36]. A cost-effectiveness study for that patient group would be the next logical step.

Delayed heart surgery is difficult to quantify due to limited available data. Data on risk of RSV-hospitalization might be different for Sweden compared to the multi-centered study used in our analysis, which may further limit the study. Other risk factors for RSV infection, such as premature birth, prenatal exposure to maternal smoking and exposure to environmental tobacco smoke, lack of breastfeeding, living in crowded households, low birth weight, day care attendance among older siblings in the household, and increased risk for nosocomial infections have not been considered in this study, which may limit the overall aspects of RSV-prophylatic treatement [50,51,52]. Prophylactic treatment can therefor include information to parents and healthcare staff of the risk for severe viral infection in children with all types of CHD, and with special attention to the risk of nosocomial infection. The effect of this precaution is difficult to evaluate but may also reduce hospitalization rates.


This study confirms that Swedish guidelines on RSV-prophylaxis with severe CHD in infants less than 1 year of age is cost effective. Avoiding delayed heart surgeries is an important aspect of the prophylaxis’ benefits and should be taken into consideration. However, further studies on the frequency and costs of delayed heart surgery are also needed to gain a better understanding of the impact RSV on society.

Availability of data and materials

The data that support the findings of this study are available in/from sources referred to in the manuscript, reference-list and Table 1.



congenital heart disease


continuous positive airway pressure


extracorporeal membrane oxygenation


incremental cost-effectiveness ratios


intensive care


lower respiratory tract infections


pediatric intensive care unit


quality-adjusted life-years


Respiratory syncytial virus


  1. 1.

    Aujard Y, Fauroux B. Risk factors for severe respiratory syncytial virus infection in infants. Respir Med. 2002;96(Suppl B):S9–14.

    PubMed  Google Scholar 

  2. 2.

    Law BJ, Carbonell-Estrany X, Simoes EA. An update on respiratory syncytial virus epidemiology: a developed country perspective. Respir Med. 2002;96(Suppl B):S1–7.

    PubMed  Google Scholar 

  3. 3.

    Fixler DE. Respiratory syncytial virus infection in children with congenital heart disease: a review. Pediatr Cardiol. 1996;17(3):163–8.

    CAS  PubMed  Google Scholar 

  4. 4.

    Kristensen K, et al. Chronic diseases, chromosomal abnormalities, and congenital malformations as risk factors for respiratory syncytial virus hospitalization: a population-based cohort study. Clin Infect Dis. 2012;54(6):810–7.

    PubMed  Google Scholar 

  5. 5.

    Jackson DJ, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008;178(7):667–72.

    PubMed  PubMed Central  Google Scholar 

  6. 6.

    Mohapatra SS, Boyapalle S. Epidemiologic, experimental, and clinical links between respiratory syncytial virus infection and asthma. Clin Microbiol Rev. 2008;21(3):495–504.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. 7.

    Sigurs N, et al. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am J Respir Crit Care Med. 2005;171(2):137–41.

    PubMed  Google Scholar 

  8. 8.

    Henderson J, et al. Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study. Pediatr Allergy Immunol. 2005;16(5):386–92.

    PubMed  Google Scholar 

  9. 9.

    Khongphatthanayothin A, et al. Impact of respiratory syncytial virus infection on surgery for congenital heart disease: postoperative course and outcome. Crit Care Med. 1999;27(9):1974–81.

    CAS  PubMed  Google Scholar 

  10. 10.

    Moynihan K, et al. Impact of viral respiratory pathogens on outcomes after pediatric cardiac surgery. Pediatr Crit Care Med. 2017;18(3):219–27.

    PubMed  Google Scholar 

  11. 11.

    Nicolas RT, et al. Early outcome after Glenn shunt and Fontan palliation and the impact of operation during viral respiratory season: analysis of a 19-year multi-institutional experience. Ann Thorac Surg. 2005;79(2):613–7 discussion 617.

    PubMed  Google Scholar 

  12. 12.

    Andabaka, T., et al., Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children. Cochrane Database Syst Rev, 2013, Issue 4. Art. No.: CD006602. DOI:

  13. 13.

    Feltes TF, et al. Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart disease. J Pediatr. 2003;143(4):532–40.

    CAS  PubMed  Google Scholar 

  14. 14.

    Resch B. Respiratory syncytial virus infection in high-risk infants - an update on Palivizumab prophylaxis. Open Microbiol J. 2014;8:71–7.

    PubMed  PubMed Central  Google Scholar 

  15. 15.

    Lofland JH, et al. Palivizumab for respiratory syncytial virus prophylaxis in high-risk infants: a cost-effectiveness analysis. Clin Ther. 2000;22(11):1357–69.

    CAS  PubMed  Google Scholar 

  16. 16.

    Bentley A, et al. A cost-effectiveness analysis of respiratory syncytial virus (RSV) prophylaxis in infants in the United Kingdom. Health Econ Rev. 2013;3(1):18.

    PubMed  PubMed Central  Google Scholar 

  17. 17.

    Nuijten M, Lebmeier M, Wittenberg W. Cost effectiveness of palivizumab for RSV prevention in high-risk children in the Netherlands. J Med Econ. 2009;12(4):291–300.

    PubMed  Google Scholar 

  18. 18.

    Resch B, et al. Cost-effectiveness of palivizumab for respiratory syncytial virus infection in high-risk children, based on long-term epidemiologic data from Austria. Pediatr Infect Dis J. 2012;31(1):e1–8.

    PubMed  Google Scholar 

  19. 19.

    Harris KC, et al. Economic evaluation of palivizumab in children with congenital heart disease: a Canadian perspective. Can J Cardiol. 2011;27(4):523 e11–5.

    PubMed  Google Scholar 

  20. 20.

    Meberg A, Bruu AL. Respiratory syncytial virus infections in congenital heart defects--hospitalizations and costs. Acta Paediatr. 2006;95(4):404–6.

    PubMed  Google Scholar 

  21. 21.

    Hussman JM, Lanctot KL, Paes B. The cost effectiveness of palivizumab in congenital heart disease: a review of the current evidence. J Med Econ. 2013;16(1):115–24.

    CAS  PubMed  Google Scholar 

  22. 22.

    Drummond, M.F., et al., Methods for the Economic Evaluation of Health Care Programmes. 4th ed. 2015: Oxford University.

  23. 23.

    Neovius K, et al. Cost-effectiveness analysis of palivizumab as respiratory syncytial virus prophylaxis in preterm infants in Sweden. Acta Paediatr. 2011;100(10):1306–14.

    PubMed  Google Scholar 

  24. 24.

    Naumburg, E.F., E. Sunnegårdh, J. Lundell, B. Nationell rekommendation för profylax med Palivizumab mot RSV-infektion hos barn med hjärtsjukdom. 2013.

  25. 25.

    TLV, Tandvård- och läkemedels-förmånsverkets allmänna råd. 2015.

    Google Scholar 

  26. 26.

    Wang, D., S. Bayliss, and C. Meads, Palivizumab for immunoprophylaxis of respiratory syncytial virus (RSV) bronchiolitis in high-risk infants and young children: a systematic review and additional economic modelling of subgroup analyses. Health Technol Assess, 2011. 15(5): iii-iv, 1-124.

  27. 27.

    Khan JY, et al. Role of ECMO in the treatment of respiratory syncytial virus bronchiolitis: a collaborative report. Arch Dis Child Fetal Neonatal Ed. 1995;73(2):F91–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  28. 28.

    Sigurs N, et al. Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax. 2010;65(12):1045–52.

    PubMed  Google Scholar 

  29. 29.

    Sigurs N, et al. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls. Pediatrics. 1995;95(4):500–5.

    CAS  PubMed  Google Scholar 

  30. 30.

    Geskey JM, Cyran SE. Managing the morbidity associated with respiratory viral infections in children with congenital heart disease. Int J Pediatr. 2012;2012:646780.

    Article  PubMed  PubMed Central  Google Scholar 

  31. 31.

    Geskey JM, Thomas NJ, Brummel GL. Palivizumab: a review of its use in the protection of high risk infants against respiratory syncytial virus (RSV). Biologics. 2007;1(1):33–43.

    CAS  PubMed  PubMed Central  Google Scholar 

  32. 32.

    Greenough A. Role of ventilation in RSV disease: CPAP, ventilation, HFO, ECMO. Paediatr Respir Rev. 2009;10(Suppl 1):26–8.

    PubMed  Google Scholar 

  33. 33.

    SSVR, Regionala priser och ersättningar för Södra sjukvårdsregionen 2019 - Södra sjukvårdsregionen. 2019.

    Google Scholar 

  34. 34.

    SÖSVR, Priser och ersättningar för Sydöstra sjukvårdsregionen 2019. 2019.

    Google Scholar 

  35. 35.

    Statistics Sweden. Sammanräknad förvärvsinkomst för boende i Sverige hela året efter region, kön, ålder och inkomstklass. År 1999–2018. 2018 [cited 2019 19 December]; Available from:

  36. 36.

    Granbom E, Fernlund E, Sunnegårdh J, Lundell B, Naumburg E. Respiratory Tract Infection and Risk of Hospitalization in Children with Congenital Heart Defects During Season and Off-Season: A Swedish National Study. Pediatr Cardiol. 2016;37(6):1098-105.

  37. 37.

    Greenough A, et al. Health care utilisation of prematurely born, preschool children related to hospitalisation for RSV infection. Arch Dis Child. 2004;89(7):673–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  38. 38.

    Chiou CF, et al. Development of the multi-attribute pediatric asthma health outcome measure (PAHOM). Int J Qual Health Care. 2005;17(1):23–30.

    PubMed  Google Scholar 

  39. 39.

    Tandvårds- och läkemedelsförmånsverket, Ändring i Tandvårds- och läkemedelsförmånsverkets allmänna råd (TLVAR 2003:2) om ekonomiska utvärderingar. 2017.

  40. 40.

    Mandalenakis Z, et al. Survivorship in children and young adults with congenital heart disease in Sweden. JAMA Intern Med. 2017;177(2):224–30.

    PubMed  Google Scholar 

  41. 41.

    Wren C, O'Sullivan JJ. Survival with congenital heart disease and need for follow up in adult life. Heart. 2001;85(4):438–43.

    CAS  PubMed  PubMed Central  Google Scholar 

  42. 42.

    Gurvitz M, et al. Emerging research directions in adult congenital heart disease: a report from an NHLBI/ACHA working group. J Am Coll Cardiol. 2016;67(16):1956–64.

    PubMed  PubMed Central  Google Scholar 

  43. 43.

    Granbom E, et al. Evaluating national guidelines for the prophylactic treatment of respiratory syncytial virus in children with congenital heart disease. Acta Paediatr. 2014;103(8):840–5.

    CAS  PubMed  Google Scholar 

  44. 44.

    Arnlind MH, et al. The relationship between pharmaceutical costs, disease severity, and health-related quality of life in asthmatics in Swedish primary care. J Asthma. 2006;43(8):585–91.

    PubMed  Google Scholar 

  45. 45.

    Hederos CA, Janson S, Hedlin G. Six-year follow-up of an intervention to improve the management of preschool children with asthma. Acta Paediatr. 2009;98(12):1939–44.

    PubMed  Google Scholar 

  46. 46.

    Socialstyrelsen. National Board of Health and Welfare 2016; Available from:

  47. 47.

    Nuijten M, Lebmeier M, Wittenberg W. Cost effectiveness of palivizumab in children with congenital heart disease in Germany. J Med Econ. 2009;12(4):301–8.

    PubMed  Google Scholar 

  48. 48.

    Nuijten MJ, Wittenberg W. Cost effectiveness of palivizumab in Spain: an analysis using observational data. Eur J Health Econ. 2010;11(1):105–15.

    PubMed  Google Scholar 

  49. 49.

    Simoes EA, et al. Palivizumab prophylaxis, respiratory syncytial virus, and subsequent recurrent wheezing. J Pediatr. 2007;151(1):34–42 42 e1.

    CAS  PubMed  Google Scholar 

  50. 50.

    Thorburn K. Pre-existing disease is associated with a significantly higher risk of death in severe respiratory syncytial virus infection. Arch Dis Child. 2009;94(2):99–103.

    CAS  PubMed  Google Scholar 

  51. 51.

    Groothuis JR, Hoopes JM, Hemming VG. Prevention of serious respiratory syncytial virus-related illness. II: Immunoprophylaxis. Adv Ther. 2011;28(2):110–25.

    PubMed  Google Scholar 

  52. 52.

    Groothuis JR, Hoopes JM, Jessie VG. Prevention of serious respiratory syncytial virus-related illness. I: disease pathogenesis and early attempts at prevention. Adv Ther. 2011;28(2):91–109.

    PubMed  PubMed Central  Google Scholar 

Download references


EF received research-time by funding from Region Östergötland (ALF) and the Medical Research Council of Southeast Sweden (FORSS).

The authors wish to thank Rongrong Zhang, formerly an AbbVie employee, for valuable input to the study design and initial data analysis.”

Financial disclosure

The design, study conduct, and financial support for the study were provided by AbbVie. AbbVie participated in the study design, data analysis, interpretation of results, review, and approval of the publication. The authors determined the final content. No payments were made to the authors for writing this publication. Open access funding provided by Umea University.

Author information




AbbVie participated in the study design, retrieval of data, data analysis, review and approval of the publication. The authors interpreted the results and determined the final content. Dr. Estelle Naumburg had primary responsibility for study, protocol development, and writing the manuscript. Martin Eriksson had the performed the health economic analysis with input from Dr. Jonas Söderholm and contributed to the writing of the manuscript. Dr. Eva Fernlund and Jan Sunnegardh participated by acquisition of county council price list and clinical data, in the analytical framework for the study and contributed to the writing of the manuscript.

Corresponding author

Correspondence to Estelle Naumburg.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

EF, JaS, and EN have nothing to disclose. ME and JoS are employed by AbbVie and may hold AbbVie stocks or stock options.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information



Table 3 Results from one-way sensitivity analysis of the base case
Table 4 The variables used in the probabilistic sensitivity analysis, with their associated uncertainty and distributions
Table 5 Costs, effects and incremental cost-effectiveness ratios (ICER) for different scenarios. Data are expressed as mean value per infant
Fig. 3

ICER scatter plot from the probabilistic sensitivity analysis

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Fernlund, E., Eriksson, M., Söderholm, J. et al. Cost-effectiveness of palivizumab in infants with congenital heart disease: a Swedish perspective. J Congenit Heart Dis 4, 5 (2020).

Download citation


  • Congenital heart defect
  • Cost-effectiveness analyses
  • Palivizumab
  • Prophylaxis
  • RSV-infection