Table 4 The variables used in the probabilistic sensitivity analysis, with their associated uncertainty and distributions
From: Cost-effectiveness of palivizumab in infants with congenital heart disease: a Swedish perspective
Variable | Mean value | Standard error (SE) | Distribution |
|---|---|---|---|
Risk of RSV-hospitalization | 9.7% | 0.010 | beta |
HR RSV hospitalization (proph) | 0.55 | 0.055 | lognormal |
Death from RSV hospitalization | 3.7% | 0.004 | beta |
Proportion delayed surgeries due to RSV-hosp | 30.0% | 0.030 | beta |
Proportion general complication from delayed surgery | 40.0% | 0.040 | beta |
Death (compl., delayed surgery) | 1.0% | 0.001 | beta |
LOS, RSV hospitalization | 13.27 | 1.33 | gamma |
LOS, RSV hospitalization (proph) | 10.79 | 1.08 | gamma |
LOS, ICU | 7.32 | 0.73 | gamma |
LOS, ICU (proph) | 2.97 | 0.30 | gamma |
Days with suppl. Oxygen | 10.44 | 1.04 | gamma |
Days with suppl. Oxygen (proph) | 5.24 | 0.52 | gamma |
Days with mechanical ventilation | 5.62 | 0.56 | gamma |
Days with mechanical ventilation (proph) | 1.24 | 0.12 | gamma |
Days with ECMO | 8.17 | 0.82 | gamma |
Days with ECMO (proph) | 8.17 | 0.82 | gamma |
Days with CPAP | 3.50 | 0.35 | gamma |
Days with CPAP (proph) | 3.50 | 0.35 | gamma |
RSV hosp (cost per day) | 1197 EUR | 120 | gamma |
ICU (cost per day) | 605 EUR1 | 60 | gamma |
Suppl. oxygen (cost per day) | 344 EUR | 34 | gamma |
Mechanical ventilation (cost per day) | 344 EUR | 34 | gamma |
ECMO (cost per day) | 8592 EUR | 859 | gamma |
CPAP (cost per day) | 2141 EUR | 214 | gamma |
first injection (kg) | 5.00 | 0.50 | normal |
second injection (kg) | 5.40 | 0.54 | normal |
third injection (kg) | 5.80 | 0.58 | normal |
fourth injection (kg) | 6.40 | 0.64 | normal |
fifth injection (kg) | 7.00 | 0.70 | normal |
Annual cost asthma | 1440 EUR | 144 | gamma |
Cost of general CHD-complication (annual) | 21,506 EUR | 2151 | gamma |
Base utility | 0.89 | 0.089 | beta |
Utility decrement of RSV hosp | 0.10 | 0.010 | beta |
Asthma utility | 0,79 | 0,079 | beta |
Utility decrement of heart complication | 0,10 | 0,010 | beta |