- Research article
- Open Access
Patterns, prevalence, risk factors, and survival of newborns with congenital heart defects in a Saudi population: a three-year, cohort case-control study
Journal of Congenital Cardiology volume 3, Article number: 2 (2019)
Congenital heart defects (CHD) are the most common types of birth defects. The prevalence of CHD, mostly from retrospective studies, ranges between 2.1 and 10.7/1000 live births. For physicians to provide appropriate health care, it is important to know the prevalence of CHD within their patient populations. In this prospective study, we assessed the prevalence, risk factors, types, and survival of CHD among babies born to Saudi mothers over a three-year period.
In this prospective cohort study, all women delivered at Prince Sultan Military Medical City, Saudi Arabia over a three-year period and were recruited during their antenatal care visits or at delivery. Antenatal foetal anomaly scan, postnatal clinical examination, echocardiography, cardiac catheterization, and follow-up to 2 years of age were used to assess the patterns, prevalence, and survival of babies with CHD. A case-control study was nested within the original cohort to assess risk factors for CHD.
Of 28,646 eligible births, 424 babies were diagnosed with CHD (14.8/1000 births), and 91 of these babies had severe CHD (3.2/1000 births). Associated non-cardiac anomalies were found in 40.1% (170 of 424) of these babies. Trisomy 21 was the most frequent chromosomal anomaly. Within the first 2 years of life, 74 of 424 babies died (17.4%). Among mothers with infants who had CHD without associated non-cardiac anomalies, risk factors for CHD included maternal age ≥ 31 years, body mass index ≥30, insulin-dependent diabetes, and an occupation of an unemployed housewife.
In the Saudi population we studied, the prevalence of CHD was higher than reported in other populations in the Middle East and in Europe. Plans to ameliorate modifiable risk factors and improve prenatal diagnosis of CHD are needed.
Congenital heart defects (CHD) are the most common types of major birth defects (BD) reported in the literature. CHD is the leading cause of birth defect-associated infant death and illness. This BD has a major effect on the quality of life for both the affected infants who survive with CHD and their families . The patterns and prevalence of CHD vary between studies [2, 3]. The prevalence of CHD reported in different studies ranges from 4/1000–50/1000 live births . In a recent systematic review of CHD in Saudi Arabia, the incidence ranged between 2.1 and 10.7 per 1000 persons . Van der Linde et al. reported on the birth prevalence of CHD diagnosed worldwide and found that the highest prevalence of CHD at 9.3/1000 live births was in Asian countries, and the lowest prevalence of CHD was 1.9/1000 live births in African nations . Data on CHD prevalence and patterns in the Middle East, based on tertiary cardiac centres or from retrospective hospital-based analyses, vary widely [5,6,7]. One regional study from Saudi Arabia showed a very high prevalence of severe CHD (5.4/1000 live births) . Prenatal diagnosis allows for improved perioperative outcomes for some severe CHD . A high prenatal detection rate of CHD has been demonstrated in other countries but has not been examined in Saudi Arabia.
None of the studies from Saudi Arabia examined the known risk factors for CHD (insulin-dependent maternal diabetes mellitus, consanguinity, high maternal age, high parity, high maternal BMI, folic acid supplementation, sex, and medication exposure during the first trimester of pregnancy) or reported infant survival prospectively.
The aim of this study was to report the prevalence, patterns, risk factors, and survival of infants with CHD in an actual Saudi population of newborns over several years. This prospective cohort study included a nested case-control study to assess the contributions of the various risk factors to CHD.
Patients: cases and controls
Inclusion criteria: The eligible cohort included all pregnant Saudi women who delivered at Prince Sultan Military Medical City (PSMMC) from 1 July 2010 through 30 June 2013. Only wives of Saudi army personnel were included in this study. Women who had an antenatal foetal anomaly scan (AFAS) between 18 and 22 weeks of gestation were enrolled in the study before the result of the anomaly scan was known. Consent for cord blood collection was obtained from the parents of babies with BD for future DNA studies.
A team of paediatric cardiologists assessed all foetuses and babies with suspected CHD based either on the AFAS findings or postnatal screening physical examinations. Paediatric cardiologists performed 2D foetal echocardiography to assess foetuses with suspected CHD detected through a routine AFAS examination, and parents were advised of the findings. Newborn babies were reassessed again post-delivery. At postnatal examinations, babies with suspected CHD were referred to the paediatric cardiology team for further assessment and management. Echocardiography, cardiac catheterization, and cardiac surgery findings were utilized to confirm the type of CHD.
Special follow-up clinics led by paediatricians were created to reassess all other babies without a prenatal or neonatal diagnosis of a congenital anomaly. These babies were reassessed at 4–8 weeks of age through a clinical examination and pulse oximetry. A routine postnatal pulse oximetry test was introduced after the first year of the study for all other babies nursed in the postnatal wards. A cutoff value of 95% O2 saturation was used to detect life-threatening CHD . All babies with an O2 saturation of < 95% were referred to the paediatric cardiologist for further assessment. Babies with major BD discovered during these clinic visits were referred back to the geneticists to be reassessed and included in the study if a BD was confirmed.
Babies with isolated secundum atrial septal defect (ASD) or patent foramen ovale were reassessed by echocardiography at 6 to 12 months of age. Babies with a normal atrial septum were excluded from the study.
Congenital heart defects were classified into severe CHD and less severe CHD. We have adopted the European Concerted Action on Congenital Anomalies and Twins (EUROCAT) definition of “severe CHD”  Table 1.
All other types of CHD were considered less severe. Elective terminations of pregnancies for foetal anomalies were offered to the parents of foetuses with a lethal malformation complex. This procedure is according to the recently approved guidelines from the religious Scholars in the Kingdom of Saudi Arabia (Kingdom of Saudi Arabia, the general presidency of scholarly research and IFTA, 2011) .
Babies with isolated CHD were defined as those with CHD without any other major BD, chromosomal aberrations, and inborn errors of metabolism. The contributions of common risk factors on individual cardiac lesions were assessed only among babies with isolated CHD. The risk factors studied included maternal age ≥ 31 years, consanguinity (first and second cousins), insulin-dependent maternal diabetes mellitus, IDDM (mothers with overt diabetes mellitus and mothers with gestational diabetes on insulin), maternal body mass index (BMI) of ≥30, and parity ≥3. Maternal education (uneducated), maternal occupation (unemployed house wife), father occupation (solider), family income (< 7000 Saudi Riyal ($1866)/month, and infant sex were also included in this study.
Non-cardiac BD associated with CHD were classified into chromosomal aberration and gene mutations, specific diagnoses, genetically recognized syndromes and multiple congenital malformations (non-chromosomal and not a recognized syndrome).
Controls included a random sample of women with a normal AFAS at 18–20 weeks and newborns with no diagnosed birth defects. To select potential controls, a random sample was generated each morning by taking the list of women with a scheduled AFAS using a random number generator (http://www.random.org). If a woman was selected as a control but the foetus was found to have any BD on the AFAS, she was considered a “case”.
In 2017, our paediatric cardiologist (MA) reviewed the entire cohort of babies with CHD. Echocardiography findings, cardiac catheterization results and cardiac operative findings were utilized for the final classification of CHD.
Babies were excluded from the study if:
Pregnant mothers were referred from other hospitals because of a foetal anomaly.
Newborns with major BD, including CHD, delivered elsewhere and referred to the study centre for further evaluation and management.
Preterm babies born at < 37 completed weeks of gestation and exhibiting prematurity-related conditions, such as patent ductus arteriosus.
Newborns with isolated minor anomalies.
Mothers with spontaneous abortions at < 20 weeks of gestation.
Newborns with mothers who had their antenatal care at PSMMC and later delivered their babies elsewhere (cases and controls).
Data were exported from the registry database to Excel spreadsheets in preparation for data analyses. Summary statistics are reported as the means ± standard deviations for continuously measured variables and as percentages ± standard deviations for categorical variables. Associations between categorical variables were measured by odds ratios, and a chi-squared test was used to assess the significance of these associations. Group comparisons were performed using the independent samples t-test and an analysis of variance (ANOVA). Since the sample size was large, there were no tests of normality because both the t-test and the ANOVA methodologies are robust enough in large samples against departure from normality. When the outcome of interest was measured on the binary scale (present/absent), multivariate logistic regression models were used to evaluate the effect of potential risk factors of interest on the outcome. The Type I error rate was set at 5%. The SPSS program (IBM SPSS statistics 21.0) was used to analyse the data. A p-value of 0.05 was considered statistically significant.
During the three-year study period, 30,351 mothers (the pregnancy cohort) gave birth to 31,032 babies (the delivery cohort), including births outside the study centre. The delivery cohort included 2107 spontaneous abortions at less than 20 weeks of gestation (6.8%). Mothers giving birth outside the study centre (279/31,032, 0.9%), were not included. Of 279 women, 58 women had babies with antenatally diagnosed birth defects and 221 women with unaffected pregnancies. The remaining 28,646 eligible pregnancy outcomes represent the study cohort, including 27,726 singletons and 920 newborns from multiple births (421 sets of twins and 32 sets of triplets).
Major birth defects (isolated or multiple defects within the same newborn) were diagnosed in 1179 pregnancy outcomes with a prevalence of 41.2/1000 total births (95% CI: 38.8–43.4). CHD was diagnosed in 424 babies (36% of babies with BD) with a prevalence of 14.8/1000 total births (95% CI: 13.4–16.2). The pattern and prevalence of various types of CHD are shown in Table 2. Isolated secundum ASD was the most common CHD diagnosed with a prevalence of 4.7/1000 total births (95% CI: 4.67–4.83). Isolated ventricular septal defect (VSD) was seen in 2.69/1000 total births (95% CI: 2.1–3.3). Severe CHD was diagnosed in 7.7% of newborns with BD (91/1179) with a prevalence of 3.2/1000 total births (95% CI: 2.55–3.85). Less severe CHD was diagnosed in 333 newborns with a prevalence of 11.6/1000 total births (95% CI: 10.38–12.86).
Table 3 shows the age at diagnosis and age at death of newborns with CHD (severe and less severe). In this analysis, we excluded mothers who did not have an AFAS (185/424, 43.6%). The overall prenatal detection rate for CHD was 33% (140/424) and 58.6% (140/239) among mothers with an AFAS. The prenatal detection rate for pregnancies with an AFAS was 85.7% (54/63) for severe CHD), and the prenatal detection rate for pregnancies with an AFAS was 48.9% (86/176) for less severe CHD. Twenty-eight mothers (30.8%) who carried foetuses with severe CHD did not have an AFAS. All newborns with severe CHD detected postnatally (except one) were diagnosed within the first week after birth.
None of the pregnancies with a prenatal diagnosis of CHD were electively terminated. There were 74 (17.4% of total CHD) foetuses or newborns who died during the follow-up period, with almost all the deaths occurring in the first year of life (Table 3).
The Kaplan–Meier survival curve for babies with CHD, other BD, and controls (Fig. 1) shows that the 50% cumulative survival for babies with severe CHD was approximately 250 days compared with a survival of 1000 days for babies with all other birth defects. (p = < 0.00001).
As shown in Fig. 2, isolated CHD defects were seen in 59.9% (254/424) of the group, and associated extra-cardiac congenital malformations were found in 40.1% (170/424) of the CHD group. There were 51 of 424 (12%) babies with chromosomal aberrations, including 37 (72.5%) babies with trisomy 21. Specific diagnoses were made in 66 (66/424, 16%) babies and included renal malformations in 14 (14/66, 21.2%) babies, diaphragmatic hernia in 8 (12.1%) babies and orofacial cleft in 7 (10.6%) babies. Recognizable specific syndromes were found in 12 (12/424, 2.8%) babies and included Ellis Van Creveld in 3 (3/12, 25%) babies, Dandy-Walker syndrome in 2 (16.7%) babies, and others rare syndromes in 7 (58.3%) babies. Thirty-nine (39/424, 9.2%) of the newborns had non-chromosomal and non-syndromic multiple congenital malformations. Drug embryopathy (sodium valproate and topiramate) was found in 2 of 424 newborns (0.5%).
There were no differences in sex among the total CHD group. In the severe CHD group, there was a significant male predominance (50/91 or 54.9%) with an OR of 1.7 (95% CI: 1.13–2.66, p = 0.01).
Parental sociodemographic characteristics as risk factors for babies with CHD were analysed for all CHD, severe CHD, and CHD without associated anomalies or syndromes (I-CHD) and controls and are shown in Table 4. In our sample, 254 (254/424, 59.9%) babies had isolated CHD. Maternal age ≥ 31 years, maternal BMI ≥30, and uneducated mothers were statistically significant risk factors for the entire cohort of CHD, I-CHD, and severe CHD groups. Consanguinity, as a risk factor for the entire cohort of CHD, was statistically significant with an OR of 1.30 (95% CI: 1.04–1.62, p = 0.02) but not for the I-CHD group (OR 1.41, 95% CI: 0.92–2.16, p = 0.13).
Multivariate logistic regression analysis was applied for the total cohort of CHD, I-CHD, and severe CHD groups separately (Table 5). Maternal age ≥ 31 years, maternal BMI ≥30, insulin-dependent maternal diabetes (IDDM), and maternal occupation as an unemployed housewife were significant risk factors for CHD in all three CHD groups. Maternal IDDM was found in 10.6% (45/424) of mothers of babies with CHD compared with 3.0% of controls mothers (OR 3.8, 95% CI: 2.44–5.79, p = < 0.00001).
Multivariate logistic regression analysis for individual cardiac lesions (among the I-CHD group only) was applied for 5 risk factors as follows: maternal age ≥ 31 years, consanguinity, maternal IDDM, maternal BMI ≥30, and sex. Ventricular septal defect (VSD) was associated with maternal age ≥ 31 years (OR 1.58, 95% CI: 1.06–2.36, p = 0.02) and maternal IDDM (OR 1.75, 95% CI: 0.99–0.3.09, p = 0.05). Secundum ASD was associated with maternal IDDM (OR 2.66, 95% CI: 1.65–4.28, p = < 0.0001) and BMI ≥30 (OR 1.66, 95% CI: 1.12–2.47, p = 0.04). All other major types of CHD were not associated with these risk factors.
In our study, foetuses and/or babies with CHD were determined by an AFAS and postnatal examination over a 3-year period from a study cohort of 28,646 eligible births. The total CHD prevalence was 14.8/1000 total births, which was higher than previously reported from Saudi Arabia (2.1–10.7/1000 live births) [3, 12], Middle Eastern countries (7.1–8.6/1000 live births) [13, 14], and Western countries (7.64–11.5/1000 births) [15, 16]. The severe CHD prevalence of 3.2/1000 total births (95% CI: 2.55–3.85) was also higher than that reported by the EUROCAT Network at 2.34/1000 live births (95% CI: 2.28–2.39, p = 0.00006) . We found a high prevalence of ASD secundum and VSD, which was similar to another study from Saudi Arabia .
These differences between prevalences could be due to different study methodologies, including longitudinal vs. cross-sectional, and retrospective analysis of charts vs. prospective studies. Additionally, inclusion of trivial lesions, stillbirths, and elective terminations of pregnancies for foetal anomalies could influence the prevalence. In addition, ethnic, genetic and/or environmental risk factors, such as maternal age, maternal illness, BMI and others, influence CHD prevalence [18, 19]. Although the contributions and the mode of actions of risk factors are debated, there is increasing evidence from epidemiological studies that indicate temporal relationships between these risk factors and CHD [18, 19]. In our study, maternal age ≥ 31 years, body mass index of ≥30, parity of ≥3, uneducated mothers, unemployed housewives, insulin-dependent maternal diabetes mellitus, and consanguinity were significantly higher among mothers of affected babies than controls and may have contributed to the high prevalence of CHD in our population.
The CHD prenatal detection rate of 58.2% among mothers who had an AFAS (140/239) was slightly lower than the 68.3% prenatal detection rate recently reported . The low detection rate for the less severe CHD group in our study could be due to the high number of cases of isolated secundum ASDs (136/333, 40.8%) and isolated VSDs (77/333, 23.1%), which may be missed on an AFAS. In addition, almost half of the pregnant women who carried foetuses with I-CHD in our study (47.1%, 157/333) did not have an AFAS. Our prenatal detection rate of 85.7% (54/63) among foetuses with severe CHD is comparable to a recent report from the Netherlands with a prenatal detection rate of more than 93% among foetuses with critical heart lesions . The issue of prenatal detection for severe CHD needs to be addressed by more thorough training of ultrasonographers in antenatal ultrasound screening techniques. Improvement in prenatal diagnosis has been shown to improve the timing, mode of delivery, and immediate postnatal management of babies with CHD .
Chromosomal aberrations were the most commonly associated anomalies (51/170, 30.0%) with trisomy 21 (Down syndrome) representing 73% (37/51) of the cases. The high proportion with trisomy 21 could be explained by the high maternal age (mean age 31.6 ± 6.5, range 17–47 years) and no first trimester screening for Down syndrome in Saudi Arabia. Elective termination of pregnancy for foetal anomalies for trisomy 21 is not allowed in Saudi Arabia (unless associated with severe BDs) because of religious convictions.
We previously reported a consanguinity prevalence rate of 55% in this population . In our current analysis, consanguinity was a significant risk factor for the entire cohort of infants with CHD (OR 1.3, 95% CI: 1.04–1.81, p = 0.02) but was not significant risk factor for the group with CHD and no associated other anomalies (OR 1.41, 95% CI: 0.92–2.16, p = 0.13). This result may indicate that consanguinity as a risk factor is mediated through various inherited conditions and cases with multiple birth defects, rather than a direct effect on CHD. Consanguinity as a risk factor for CHD and for individual cardiac lesions has been widely debated [27,28,29]. In our study, the effect of consanguinity (first- and second-cousin marriage) on individual cardiac lesions (among the group of CHD without associated anomalies) was evaluated using multivariate logistic regression analysis. Consanguinity was not statistically significant for any specific cardiac defect. Other studies have reported a statistically significant association of consanguinity for specific congenital cardiac lesions [26,27,28]. Maternal insulin-dependent diabetes was a risk factor for secundum ASD and VSD only (OR 2.66, 95% CI: 1.65–4.28, p = < 0.0001 and OR 1.75, 95% CI: 0.99–3.09, p = 0.05, respectively). These results agree with those of Garne et al. using EUROCAT data .
The alarmingly high prevalence of maternal insulin-dependent diabetes of 10.6 and 3% among mothers of cases and controls (Table 4) is almost similar to 11.6% among Saudi females at 30–39 years reported by Al-Nozha et al. . In our study, maternal age was only a significant risk factor for VSD (OR 1.58, 95% CI: 1.06–2.36, p = 0.02). For other lesions, the analysis was limited due to low numbers.
The strengths of our study included the involvement of paediatric cardiologists for both prenatally and postnatally suspected cases of CHD, the inclusion of stillbirth with CHD, and the relatively long follow-up period (2–5 years).
Although the Saudi army recruits from all sectors of the Saudi society, the inclusion of only Saudi army personnel may represent a study limitation. There was a high proportion of uneducated mothers with high parity (higher than 3). Additionally, we excluded infants from mothers who delivered elsewhere (cases and controls) as we were not able to verify their AFAS findings and confirm postnatal diagnosis, which is another limitation of the study.
In this Saudi population, we report a high prevalence of CHD compared with other Middle East and Western countries. As prenatal diagnosis of CHD may improve outcomes, there is a need for a higher uptake of an AFAS in this population. We found several modifiable CHD risk factors that underscore the importance of public health programmes aimed at tackling and preventing such risk determinants for CHD, which could reduce the prevalence of CHD.
Antenatal Foetal Anomaly Scan
Atrial Septal Defect
Body Mass Index
Congenital Heart Defects
European Concerted Action on Congenital Anomalies and Twins
Insulin Dependent Diabetes Mellitus
Prince Sultan Military Medical City
Ventricular Septal Defect
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We would like to thank King Abdul-Aziz city for science and technology & NSTIP for their support to this study. We would like to thank the Medical Services Directorate of the Saudi Armed Forces and the Prince Sultan Military Medical City directorate for their unlimited support during the initiation and execution of the study. Our unlimited thanks and appreciation also goes to our advisory board (Professors; Castilla E., Mastroiacovo P., Botto L., Alkuraya F., and Dr. Kurdi W.) during the preparation/discussion of the study proposal and execution of the study. We would like to thank our secretaries for their commitment and enthusiasm.
This project was supported by a grant from King Abdul-Aziz city for science and technology through the national science, technology and innovation plan. Project No: 09-MED748–21.
Availability of data and materials
The data that support the findings of this study are available from [King AbdulAziz City for Science and Technology]. Data are however available from the authors upon reasonable request and with permission of [King AbdulAziz City for Science and Technology].
Consent of participant
Parental request was obtained for cord blood collections from babies with BD for future DNA study.
Ethics approval and consent to participate
The study approved by the research and ethical Committee of PSMMC (Project No. 366, series of 2009).
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The authors declare that they have no competing interests.
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Majeed-Saidan, M.A., Atiyah, M., Ammari, A.N. et al. Patterns, prevalence, risk factors, and survival of newborns with congenital heart defects in a Saudi population: a three-year, cohort case-control study. J Congenit Heart Dis 3, 2 (2019). https://doi.org/10.1186/s40949-019-0023-8
- Congenital heart defects
- Birth defects
- Risk factors