Table 1 Summary of published series reporting pregnancies in women with Fontan hearts
Author | Zentner et ala | Cauldwell et al | Gouton et al | Pundi et ala | Drenthen et al | Hoare and Radford | Sui et al | Cannobio et al | |
|---|---|---|---|---|---|---|---|---|---|
Year | 2016 | 2016 | 2015 | 2015 | 2006 | 2001 | 2002 | 1996 | |
Type of study | Multi-centre registry | Single-centre registry | Multi-centre registry | Single-centre registry | Multi-centre registry | Multi-centre prospective registry | Multi-centre registry | ||
Location | Australia/ New Zealand | UK | France | USA | Holland/ Belgium | Australia | Canada | USA | |
Pregnancy outcomes | No. of pregnancies | 40 | 43 | 59 | 70 | 10 | 4 | 5 | 33 |
Spontaneous miscarriages | 9 (39%) | 28 (65%) | 16 (27%) | 35 (50%) | 5 (50%) | - | - | 13 (39%) | |
Terminations | 7.5% | 4 (7%) | 6 (9%) | 1 (10%) | - | - | 5 (15%) | ||
Live births | 15 (38%)b | 14 | 39 (66%)b | 29 (41%) | 4 (40%) | 4 | 5 | 15 (46%) | |
No. of women with live births | - | 8 | - | - | 3 | 3 | 3 | 14 | |
Maternal deaths | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
Maternal Complications | CVS | 1/14 - arrhythmia | 5/14 (36%) – 4 arrhythmias and 1 thromboembolism | 6/59 (10%) women had CVS events – 3 arrhythmias, 3 heart failure | 7 women had arrhythmia | 1 woman AF and 2 women had decline in NYHA class | 2 women –arrhythmia and heart failure | - | 3 women −1 heart failure, 1 valvular regurgitation and 1 SVT |
Obstetric | 7/14 | 7/14 (50%) PPH, | 3 APH; 2 VTE | - | 1 PPH | - | - | None | |
Fetal outcomes | Preterm delivery | 10/14 (71%) | 25/36 (69%)a | 18/22 (81%)a | 2 (50%) | 4 (100%) | - | 1 (7%) | |
Gestation length (weeks) | 31.5 | 34 (range 29–40) | 34.0±4.0 | 33.1±4.0a | - | 31 (range 26–35) | - | 38 (range 28–40) |